讲座预告 | 哈佛大学医学院张毅教授

学

者

讲

坛

＋生物结构前沿＋

“

时间

2024年10月29日（星期二） 

10:30-12:00

地点

清华大学生命科学馆143

主持人

颉伟教授和李海涛教授

嘉宾简介

Dr. Yi Zhang

Fred Rosen Chair Professor, Harvard Medical School and Boston Children’s Hospital

Investigator, Howard Hughes Medical Institute

Yi Zhang is a Fred Rosen Chair Professor of the Department of Genetics and Department of Pediatrics of the Harvard Medical School and Boston Children’s Hospital. His major interest has been the epigenetic basis of gene expression in embryonic development, stem cell reprogramming and aging, as well as reward-related brain learning and memory. He is also interested in how dysregulation of epigenetic enzymes contributes to various human diseases including cancer and drug addiction.

Dr. Zhang has made fundamental contributions to the epigenetics field through systematic identifying and characterizing chromatin modifying enzymes, including the nucleosome remodeling and deacetylase (NuRD) complex, histone methyltransferases (e.g. Ezh2/PRC2, Dot1L), the JmjC-containing histone demethylases, histone H2A ubiquitin E3 ligase PRC1, and the TET family of 5-methylcytosine dioxygenases. In addition to identifying these critical epigenetic enzymes, he contributed in elucidation the mechanisms underlying classic epigenetic phenomena, including Polycomb silencing, genomic imprinting, and X-chromosome inactivation. Furthermore, his lab has greatly improved the animal cloning technology by identifying and overcoming two of the most important epigenetic barriers of cloning, as well as helped in developing PRC2/EZH2 inhibitor tazemetostat, an FDA approved drug for epithliod sarcoma and follicular lymphoma. Dr. Zhang was named a Top 10 author of high impact papers in Genetics and Molecular Biology (2002-2006), and one of the most influential scientists in the world by ScienceWatch. He has published over 190 high impact papers with more than 90,000 citations and an H-index of 123.

生物结构前沿

学者讲坛

传播“有思想的学术”，启迪“有学术的思想”。生物结构前沿学者讲坛，旨在邀请青年学者，讲述生命科学的学术传承、治学机缘和科学理念，以彰显当代科研学者的精神风貌和学术追求。本系列讲坛以“研究问题，交流思想，学术探讨，创新理念”为核心，在促进学科交叉融合，营造良好学术氛围的基础上，感悟学术创新之乐趣，科学传承之不息。

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